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Title:

In vivo functional dissection of a context-dependent role for Hif1? in pancreatic tumorigenesis.

Document type:
Journal Article
Author(s):
Cheng, T; Jian, Z; Li, K; Raulefs, S; Regel, I; Shen, S; Zou, X; Ruland, J; Ceyhan, G O; Friess, H; Michalski, C W; Kleeff, J; Kong, B
Abstract:
Hypoxia-inducible factor 1? (Hif1?) is a key regulator of cellular adaptation and survival under hypoxic conditions. In pancreatic ductal adenocarcinoma (PDAC), it has been recently shown that genetic ablation of Hif1? accelerates tumour development by promoting tumour-supportive inflammation in mice, questioning its role as the key downstream target of many oncogenic signals of PDAC. Likely, Hif1? has a context-dependent role in pancreatic tumorigenesis. To further analyse this, murine PDAC cel...     »
Journal title abbreviation:
Oncogenesis
Year:
2016
Journal volume:
5
Journal issue:
12
Pages contribution:
e278
Language:
eng
Fulltext / DOI:
doi:10.1038/oncsis.2016.78
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27941931
Print-ISSN:
2157-9024
TUM Institution:
Chirurgische Klinik und Poliklinik; Institut für Klinische Chemie und Pathobiochemie
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