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Title:

Vav Proteins Are Key Regulators of Card9 Signaling for Innate Antifungal Immunity.

Document type:
Journal Article
Author(s):
Roth, Susanne; Bergmann, Hanna; Jaeger, Martin; Yeroslaviz, Assa; Neumann, Konstantin; Koenig, Paul-Albert; Prazeres da Costa, Clarissa; Vanes, Lesley; Kumar, Vinod; Johnson, Melissa; Menacho-Márquez, Mauricio; Habermann, Bianca; Tybulewicz, Victor L; Netea, Mihai; Bustelo, Xosé R; Ruland, Jürgen
Abstract:
Fungal infections are major causes of morbidity and mortality, especially in immunocompromised individuals. The innate immune system senses fungal pathogens through Syk-coupled C-type lectin receptors (CLRs), which signal through the conserved immune adaptor Card9. Although Card9 is essential for antifungal defense, the mechanisms that couple CLR-proximal events to Card9 control are not well defined. Here, we identify Vav proteins as key activators of the Card9 pathway. Vav1, Vav2, and Vav3 coop...     »
Journal title abbreviation:
Cell Rep
Year:
2016
Journal volume:
17
Journal issue:
10
Pages contribution:
2572-2583
Language:
eng
Fulltext / DOI:
doi:10.1016/j.celrep.2016.11.018
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27926862
Print-ISSN:
2211-1247
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie; Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
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