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Titel:

Spleen Tyrosine Kinase Is Involved in the CD38 Signal Transduction Pathway in Chronic Lymphocytic Leukemia.

Dokumenttyp:
Journal Article
Autor(en):
Benkisser-Petersen, Marco; Buchner, Maike; Dörffel, Arlette; Dühren-von-Minden, Marcus; Claus, Rainer; Kläsener, Kathrin; Leberecht, Kerstin; Burger, Meike; Dierks, Christine; Jumaa, Hassan; Malavasi, Fabio; Reth, Michael; Veelken, Hendrik; Duyster, Justus; Zirlik, Katja
Abstract:
The survival and proliferation of CLL cells depends on microenvironmental contacts in lymphoid organs. CD38 is a cell surface receptor that plays an important role in survival and proliferation signaling in CLL. In this study we demonstrate SYK's direct involvement in the CD38 signaling pathway in primary CLL samples. CD38 stimulation of CLL cells revealed SYK activation. SYK downstream target AKT was subsequently induced and MCL-1 expression was increased. Concomitant inhibition of SYK by the S...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2016
Band / Volume:
11
Heft / Issue:
12
Seitenangaben Beitrag:
e0169159
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0169159
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28036404
Print-ISSN:
1932-6203
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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