User: Guest  Login
Document type:
Journal Article; Article 
Author(s):
Raab, Susanne; Wang, Haiyan; Uhles, Sabine; Cole, Nadine; Alvarez-Sanchez, Ruben; Künnecke, Basil; Ullmer, Christoph; Matile, Hugues; Bedoucha, Marc; Norcross, Roger D; Ottaway-Parker, Nickki; Perez-Tilve, Diego; Conde Knape, Karin; Tschöp, Matthias H; Hoener, Marius C; Sewing, Sabine 
Title:
Incretin-like effects of small molecule trace amine-associated receptor 1 agonists. 
Abstract:
Type 2 diabetes and obesity are emerging pandemics in the 21st century creating worldwide urgency for the development of novel and safe therapies. We investigated trace amine-associated receptor 1 (TAAR1) as a novel target contributing to the control of glucose homeostasis and body weight.We investigated the peripheral human tissue distribution of TAAR1 by immunohistochemistry and tested the effect of a small molecule TAAR1 agonist on insulin secretion in vitro using INS1E cells and human islets...    »
 
Journal title abbreviation:
Mol Metab 
Year:
2016 
Journal volume:
Journal issue:
Pages contribution:
47-56 
TUM Institution:
Lehrstuhl für Stoffwechselerkrankungen (Prof. Tschöp)