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Titel:

Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation.

Dokumenttyp:
Journal Article; Article
Autor(en):
Lee, Heekyoung; Qian, Kun; von Toerne, Christine; Hoerburger, Lena; Claussnitzer, Melina; Hoffmann, Christoph; Glunk, Viktoria; Wahl, Simone; Breier, Michaela; Eck, Franziska; Jafari, Leili; Molnos, Sophie; Grallert, Harald; Dahlman, Ingrid; Arner, Peter; Brunner, Cornelia; Hauner, Hans; Hauck, Stefanie M; Laumen, Helmut
Abstract:
Genome-wide association studies identified numerous disease risk loci. Delineating molecular mechanisms influenced by cis-regulatory variants is essential to understand gene regulation and ultimately disease pathophysiology. Combining bioinformatics and public domain chromatin information with quantitative proteomics supports prediction of cis-regulatory variants and enabled identification of allele-dependent binding of both, transcription factors and coregulators at the type 2 diabetes associat...     »
Zeitschriftentitel:
Nucleic Acids Res
Jahr:
2017
Band / Volume:
45
Heft / Issue:
6
Seitenangaben Beitrag:
3266-3279
Sprache:
eng
Volltext / DOI:
doi:10.1093/nar/gkx105
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28334807
Print-ISSN:
0305-1048
TUM Einrichtung:
Else Kröner-Fresenius-Zentrum für Ernährungsmedizin - Klinik für Ernährungsmedizin
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