User: Guest  Login
More Searchfields
Simple search
Title:

A genetic modifier suggests that endurance exercise exacerbates Huntington's disease

Document type:
Zeitschriftenaufsatz
Author(s):
Corrochano, Silvia; Blanco, Gonzalo; Williams, Debbie; Wettstein, Jessica; Simon, Michelle; Kumar, Saumya; Moir, Lee; Agnew, Thomas; Stewart, Michelle; Landman, Allison; Kotiadis, Vassilios N; Duchen, Michael R; Wackerhage, Henning; Rubinsztein, David C; Brown, Steve D M; Acevedo-Arozena, Abraham
Abstract:
Polyglutamine expansions in the huntingtin gene cause Huntington's disease (HD). Huntingtin is ubiquitously expressed, leading to pathological alterations also in peripheral organs. Variations in the length of the polyglutamine tract explain up to 70% of the age-at-onset variance, with the rest of the variance attributed to genetic and environmental modifiers. To identify novel disease modifiers, we performed an unbiased mutagenesis screen on an HD mouse model, identifying a mutation in the skel...     »
Keywords:
Huntington's disease
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit; 790 Sport, Spiele, Unterhaltung
Journal title:
Human Molecular Genetics
Year:
2018
Journal volume:
27
Year / month:
2018-03
Quarter:
1. Quartal
Month:
Mar
Journal issue:
10
Pages contribution:
1723-1731
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1093/hmg/ddy077
WWW:
https://core.ac.uk/download/pdf/153570758.pdf
Publisher:
Oxford University Press (OUP)
E-ISSN:
0964-69061460-2083
Impact Factor:
4,9
Date of publication:
02.03.2018
Semester:
SS 19
TUM Institution:
Sportbiologie
 BibTeX