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Titel:

Analysis of the relationship between the KRAS G12V oncogene and the Hippo effector YAP1 in embryonal rhabdomyosarcoma

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Mohamed AD, Shah N, Hettmer S, Vargesson N, Wackerhage H
Abstract:
Persistent hyperactivity of the Hippo effector YAP in activated satellite cells is sufficient to cause embryonal rhabdomyosarcoma (ERMS) in mice. In humans, YAP is abundant and nuclear in the majority of ERMS cases, and high YAP expression is associated with poor survival. However, YAP1 is rarely mutated in human ERMS. Instead, the most common mutations in ERMS are oncogenic RAS mutations. First, to compare YAP1 S127A and KRAS G12V-driven rhabdomyosarcomas, we re-analysed gene expression microar...     »
Stichworte:
KRAS G12V, YAP1, rhabdomyosarcoma
Dewey Dezimalklassifikation:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit
Zeitschriftentitel:
Scientific Reports
Jahr:
2018
Band / Volume:
8
Jahr / Monat:
2018-10
Quartal:
4. Quartal
Monat:
Oct
Heft / Issue:
1
Seitenangaben Beitrag:
10
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1038/s41598-018-33852-7.
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/30353028
WWW:
https://www.nature.com/articles/s41598-018-33852-7
Verlag / Institution:
Springer
E-ISSN:
2045-2322
Impact Factor:
4.609
Publikationsdatum:
23.10.2018
Semester:
WS 18-19
TUM Einrichtung:
Sportbiologie
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