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Title:

Fatty Acid Metabolites as Novel Regulators of Non-shivering Thermogenesis

Document type:
Buchbeitrag
Author(s):
Maurer, Stefanie F.; Dieckmann, Sebastian; Kleigrewe, Karin; Colson, Cécilia; Amri, Ez-Zoubir; Klingenspor, Martin
Abstract:
Fatty acids are essential contributors to adipocyte-based non-shivering thermogenesis by acting as activators of uncoupling protein 1 and serving as fuel for mitochondrial heat production. Novel evidence suggests a contribution to this thermogenic mechanism by their conversion to bioactive compounds. Mammalian cells produce a plethora of oxylipins and endocannabinoids, some of which have been identified to affect the abundance or thermogenic activity of brown and brite adipocytes. These effector...     »
Keywords:
Brite adipocytes; Brown adipocytes; Endocannabinoids; Oxylipins; PUFAs; Thermogenesis; Ucp1; ω-3; ω-6; BayBioMS
Book title:
Handbook of Experimental Pharmacology
Publisher:
Springer Berlin Heidelberg
Year:
2018
DOI:
doi:10.1007/164_2018_150
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