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Titel:

Genome-wide genetic and epigenetic analyses of pancreatic acinar cell carcinomas reveal aberrations in genome stability.

Dokumenttyp:
Journal Article
Autor(en):
Jäkel, Cornelia; Bergmann, Frank; Toth, Reka; Assenov, Yassen; van der Duin, Daniel; Strobel, Oliver; Hank, Thomas; Klöppel, Günter; Dorrell, Craig; Grompe, Markus; Moss, Joshua; Dor, Yuval; Schirmacher, Peter; Plass, Christoph; Popanda, Odilia; Schmezer, Peter
Abstract:
Pancreatic acinar cell carcinoma (ACC) is an aggressive exocrine tumor with largely unknown biology. Here, to identify potential targets for personalized treatment, we perform integrative genome-wide and epigenome-wide analyses. The results show frequently aberrant DNA methylation, abundant chromosomal amplifications and deletions, and mutational signatures suggesting defective DNA repair. In contrast to pancreatic ductal adenocarcinoma, no recurrent point mutations are detected. The tumor suppr...     »
Zeitschriftentitel:
Nat Commun
Jahr:
2017
Band / Volume:
8
Heft / Issue:
1
Seitenangaben Beitrag:
1323
Sprache:
eng
Volltext / DOI:
doi:10.1038/s41467-017-01118-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29109526
Print-ISSN:
2041-1723
TUM Einrichtung:
Institut für Allgemeine Pathologie und Pathologische Anatomie
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