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Titel:

Herbal Traditional Chinese Medicine and suspected liver injury: A prospective study.

Dokumenttyp:
Journal Article; 29
Autor(en):
Melchart, Dieter; Hager, Stefan; Albrecht, Sabine; Dai, Jingzhang; Weidenhammer, Wolfgang; Teschke, Rolf
Abstract:
To analyze liver tests before and following treatment with herbal Traditional Chinese Medicine (TCM) in order to evaluate the frequency of newly detected liver injury.Patients with normal values of alanine aminotransferase (ALT) as a diagnostic marker for ruling out pre-existing liver disease were enrolled in a prospective study of a safety program carried out at the First German Hospital of TCM from 1994 to 2015. All patients received herbal products, and their ALT values were reassessed 1-3 d prior to discharge. To verify or exclude causality for suspected TCM herbs, the Roussel Uclaf Causality Assessment Method (RUCAM) was used.This report presents for the first time liver injury data derived from a prospective, hospital-based and large-scale study of 21470 patients who had no liver disease prior to treatment with herbal TCM. Among these, ALT ranged from 1 × to < 5 × upper limit normal (ULN) in 844 patients (3.93%) and suggested mild or moderate liver adaptive abnormalities. However, 26 patients (0.12%) experienced higher ALT values of >= 5 × ULN (300.0 ± 172.9 U/L, mean ± SD). Causality for TCM herbs was RUCAM-based probable in 8/26 patients, possible in 16/26, and excluded in 2/26 cases. Bupleuri radix and Scutellariae radix were the two TCM herbs most commonly implicated.In 26 (0.12%) of 21470 patients treated with herbal TCM, liver injury with ALT values of >= 5 × ULN was found, which normalized shortly following treatment cessation, also substantiating causality.
Zeitschriftentitel:
World J Hepatol
Jahr:
2017
Band / Volume:
9
Heft / Issue:
29
Seitenangaben Beitrag:
1141-1157
Sprache:
eng
Volltext / DOI:
doi:10.4254/wjh.v9.i29.1141
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/29085558
Print-ISSN:
1948-5182
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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