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Title:

Context-Dependent Epigenetic Regulation of Nuclear Factor of Activated T Cells 1 in Pancreatic Plasticity.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; 6
Author(s):
Chen, Nai-Ming; Neesse, Albrecht; Dyck, Moritz Lino; Steuber, Benjamin; Koenig, Alexander O; Lubeseder-Martellato, Clara; Winter, Thore; Forster, Teresa; Bohnenberger, Hanibal; Kitz, Julia; Reuter-Jessen, Kirsten; Griesmann, Heidi; Gaedcke, Jochen; Grade, Marian; Zhang, Jin-San; Tsai, Wan-Chi; Siveke, Jens; Schildhaus, Hans-Ulrich; Ströbel, Philipp; Johnsen, Steven A; Ellenrieder, Volker; Hessmann, Elisabeth
Abstract:
The ability of exocrine pancreatic cells to change the cellular phenotype is required for tissue regeneration upon injury, but also contributes to their malignant transformation and tumor progression. We investigated context-dependent signaling and transcription mechanisms that determine pancreatic cell fate decisions toward regeneration and malignancy. In particular, we studied the function and regulation of the inflammatory transcription factor nuclear factor of activated T cells 1 (NFATC1) in...     »
Journal title abbreviation:
Gastroenterology
Year:
2017
Journal volume:
152
Journal issue:
6
Pages contribution:
1507-1520.e15
Language:
eng
Fulltext / DOI:
doi:10.1053/j.gastro.2017.01.043
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28188746
Print-ISSN:
0016-5085
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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