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Title:

Human hepatic organoids for the analysis of human genetic diseases.

Document type:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Author(s):
Guan, Yuan; Xu, Dan; Garfin, Phillip M; Ehmer, Ursula; Hurwitz, Melissa; Enns, Greg; Michie, Sara; Wu, Manhong; Zheng, Ming; Nishimura, Toshihiko; Sage, Julien; Peltz, Gary
Abstract:
We developed an in vitro model system where induced pluripotent stem cells (iPSCs) differentiate into 3-dimensional human hepatic organoids (HOs) through stages that resemble human liver during its embryonic development. The HOs consist of hepatocytes, and cholangiocytes, which are organized into epithelia that surround the lumina of bile duct-like structures. The organoids provide a potentially new model for liver regenerative processes, and were used to characterize the effect of different JAG...     »
Journal title abbreviation:
JCI Insight
Year:
2017
Journal volume:
2
Journal issue:
17
Language:
eng
Fulltext / DOI:
doi:10.1172/jci.insight.94954
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28878125
Print-ISSN:
2379-3708
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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