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Titel:

Human hepatic organoids for the analysis of human genetic diseases.

Dokumenttyp:
Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't
Autor(en):
Guan, Yuan; Xu, Dan; Garfin, Phillip M; Ehmer, Ursula; Hurwitz, Melissa; Enns, Greg; Michie, Sara; Wu, Manhong; Zheng, Ming; Nishimura, Toshihiko; Sage, Julien; Peltz, Gary
Abstract:
We developed an in vitro model system where induced pluripotent stem cells (iPSCs) differentiate into 3-dimensional human hepatic organoids (HOs) through stages that resemble human liver during its embryonic development. The HOs consist of hepatocytes, and cholangiocytes, which are organized into epithelia that surround the lumina of bile duct-like structures. The organoids provide a potentially new model for liver regenerative processes, and were used to characterize the effect of different JAG...     »
Zeitschriftentitel:
JCI Insight
Jahr:
2017
Band / Volume:
2
Heft / Issue:
17
Sprache:
eng
Volltext / DOI:
doi:10.1172/jci.insight.94954
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28878125
Print-ISSN:
2379-3708
TUM Einrichtung:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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