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Document type:
Zeitschriftenaufsatz
Author(s):
Nezhad, Fakhreddin Yaghoob; Riermeier, Annett; Schönfelder, Martin; Becker, Lore; de Angelis, Martin Hrabĕ; Wackerhage, Henning
Title:
Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers
Abstract:
The Hippo signal transduction network regulates transcription through Yap/Taz-Tead1-4 in many tissues including skeletal muscle. Whilst transgenic mice have been generated for many Hippo genes, the resultant skeletal muscle phenotypes were not always characterized. Here, we aimed to phenotype the hindlimb muscles of Hippo gene-mutated Lats1−/−, Mst2−/−, Vgll3−/−, and Vgll4+/− mice. This analysis revealed that Lats1−/− mice have 11% more slow type I fibers than age and sex-matched wild-type contr...    »
Dewey Decimal Classification:
570 Biowissenschaften, Biologie
Journal title:
Transgenic Research
Year:
2022
Year / month:
2022-01
Quarter:
1. Quartal
Month:
Jan
Covered by:
Web of Science
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1007/s11248-021-00293-4
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/34984591
WWW:
https://link.springer.com/article/10.1007/s11248-021-00293-4
Publisher:
Springer Science and Business Media LLC
E-ISSN:
0962-88191573-9368
Impact Factor:
2,58
Scimago Quartil:
Q1
Notes:
SCImago Journal &  Country Rank
Status:
Erstveröffentlichung
Date of publication:
05.01.2022
Semester:
WS 21-22
TUM Institution:
Sportbiologie
Format:
Bild/Text
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