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Title:

Genes Whose Gain or Loss-Of-Function Increases Skeletal Muscle Mass in Mice: A Systematic Literature Review

Document type:
Zeitschriftenaufsatz
Author(s):
Verbrugge SAJ, Schoenfelder M, Becker L, Yaghoob Nezhad F, Hrabě de Angelis M, Wackerhage H
Abstract:
Skeletal muscle mass differs greatly in mice and humans and this is partially inherited. To identify muscle hypertrophy candidate genes we conducted a systematic review to identify genes whose experimental loss or gain-of-function results in significant skeletal muscle hypertrophy in mice. We found 47 genes that meet our search criteria and cause muscle hypertrophy after gene manipulation. They are from high to small effect size: Ski, Fst, Acvr2b, Akt1, Mstn, Klf10, Rheb, Igf1, Pappa, Ppard...     »
Keywords:
skeletal muscle, hypertrophy, gene manipulation, mutation, GWAS, sarcopenia, myostatin, resistance exercise
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit; 790 Sport, Spiele, Unterhaltung
Journal title:
Frontiers in Physiology
Year:
2018
Journal volume:
9
Year / month:
2018-05
Quarter:
2. Quartal
Month:
May
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.3389/fphys.2018.00553
Publisher:
Frontiers
E-ISSN:
1664-042X
Impact Factor:
4.134
Semester:
SS 18
TUM Institution:
Sportbiologie
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