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Titel:

Skeletal muscle phenotyping of Hippo gene-mutated mice reveals that Lats1 deletion increases the percentage of type I muscle fibers

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Nezhad, Fakhreddin Yaghoob; Riermeier, Annett; Schönfelder, Martin; Becker, Lore; de Angelis, Martin Hrabĕ; Wackerhage, Henning
Abstract:
The Hippo signal transduction network regulates transcription through Yap/Taz-Tead1-4 in many tissues including skeletal muscle. Whilst transgenic mice have been generated for many Hippo genes, the resultant skeletal muscle phenotypes were not always characterized. Here, we aimed to phenotype the hindlimb muscles of Hippo gene-mutated Lats1−/−, Mst2−/−, Vgll3−/−, and Vgll4+/− mice. This analysis revealed that Lats1−/− mice have 11% more slow type I fibers than age and sex-matched wild-type contr...     »
Dewey Dezimalklassifikation:
570 Biowissenschaften, Biologie
Zeitschriftentitel:
Transgenic Research
Jahr:
2022
Jahr / Monat:
2022-01
Quartal:
1. Quartal
Monat:
Jan
Nachgewiesen in:
Web of Science
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.1007/s11248-021-00293-4
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/34984591
WWW:
https://link.springer.com/article/10.1007/s11248-021-00293-4
Verlag / Institution:
Springer Science and Business Media LLC
E-ISSN:
0962-88191573-9368
Impact Factor:
2,58
Scimago-Quartil:
Q1
Hinweise:
SCImago Journal &  Country Rank
Status:
Erstveröffentlichung
Publikationsdatum:
05.01.2022
Semester:
WS 21-22
TUM Einrichtung:
Sportbiologie
Format:
Bild/Text
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