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Document type:
Journal Article; Review 
Author(s):
Allen, Richard P; Donelson, Nathan C; Jones, Byron C; Li, Yuqing; Manconi, Mauro; Rye, David B; Sanyal, Subhabrata; Winkelmann, Juliane 
Title:
Animal models of RLS phenotypes. 
Abstract:
Restless legs syndrome (RLS) is a complex disorder that involves sensory and motor systems. The major pathophysiology of RLS is low iron concentration in the substantia nigra containing the cell bodies of dopamine neurons that project to the striatum, an area that is crucial for modulating movement. People who have RLS often present with normal iron values outside the brain; recent studies implicate several genes are involved in the syndrome. Like most complex diseases, animal models usually do...    »
 
Journal title abbreviation:
Sleep Med 
Year:
2017 
Journal volume:
31 
Pages contribution:
23-28 
Language:
eng 
Print-ISSN:
1389-9457 
TUM Institution:
Lehrstuhl für Neurogenetik (Prof. Winkelmann)