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Title:

Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Rothwell, Simon; Cooper, Robert G; Lundberg, Ingrid E; Gregersen, Peter K; Hanna, Michael G; Machado, Pedro M; Herbert, Megan K; Pruijn, Ger J M; Lilleker, James B; Roberts, Mark; Bowes, John; Seldin, Michael F; Vencovsky, Jiri; Danko, Katalin; Limaye, Vidya; Selva-O'Callaghan, Albert; Platt, Hazel; Molberg, Øyvind; Benveniste, Olivier; Radstake, Timothy R D J; Doria, Andrea; De Bleecker, Jan; De Paepe, Boel; Gieger, Christian; Meitinger, Thomas; Winkelmann, Juliane; Amos, Christopher I; Ollier,...     »
Abstract:
Inclusion body myositis (IBM) is characterized by a combination of inflammatory and degenerative changes affecting muscle. While the primary cause of IBM is unknown, genetic factors may influence disease susceptibility. To determine genetic factors contributing to the etiology of IBM, we conducted the largest genetic association study of the disease to date, investigating immune-related genes using the Immunochip.A total of 252 Caucasian patients with IBM were recruited from 11 countries through...     »
Journal title abbreviation:
Arthritis Rheumatol
Year:
2017
Journal volume:
69
Journal issue:
5
Pages contribution:
1090-1099
Language:
eng
Fulltext / DOI:
doi:10.1002/art.40045
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28086002
Print-ISSN:
2326-5191
TUM Institution:
Institut für Humangenetik; Lehrstuhl für Neurogenetik (Prof. Winkelmann)
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