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Titel:

Immune-Array Analysis in Sporadic Inclusion Body Myositis Reveals HLA-DRB1 Amino Acid Heterogeneity Across the Myositis Spectrum.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Rothwell, Simon; Cooper, Robert G; Lundberg, Ingrid E; Gregersen, Peter K; Hanna, Michael G; Machado, Pedro M; Herbert, Megan K; Pruijn, Ger J M; Lilleker, James B; Roberts, Mark; Bowes, John; Seldin, Michael F; Vencovsky, Jiri; Danko, Katalin; Limaye, Vidya; Selva-O'Callaghan, Albert; Platt, Hazel; Molberg, Øyvind; Benveniste, Olivier; Radstake, Timothy R D J; Doria, Andrea; De Bleecker, Jan; De Paepe, Boel; Gieger, Christian; Meitinger, Thomas; Winkelmann, Juliane; Amos, Christopher I; Ollier,...     »
Abstract:
Inclusion body myositis (IBM) is characterized by a combination of inflammatory and degenerative changes affecting muscle. While the primary cause of IBM is unknown, genetic factors may influence disease susceptibility. To determine genetic factors contributing to the etiology of IBM, we conducted the largest genetic association study of the disease to date, investigating immune-related genes using the Immunochip.A total of 252 Caucasian patients with IBM were recruited from 11 countries through...     »
Zeitschriftentitel:
Arthritis Rheumatol
Jahr:
2017
Band / Volume:
69
Heft / Issue:
5
Seitenangaben Beitrag:
1090-1099
Sprache:
eng
Volltext / DOI:
doi:10.1002/art.40045
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28086002
Print-ISSN:
2326-5191
TUM Einrichtung:
Institut für Humangenetik; Lehrstuhl für Neurogenetik (Prof. Winkelmann)
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