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Title:

IL-1? and IL-23 Promote Extrathymic Commitment of CD27+CD122- ?? T Cells to ??T17 Cells.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Muschaweckh, Andreas; Petermann, Franziska; Korn, Thomas
Abstract:
??T17 cells are a subset of ?? T cells committed to IL-17 production and are characterized by the expression of IL-23R and CCR6 and lack of CD27 expression. ??T17 cells are believed to arise within a narrow time window during prenatal thymic development. In agreement with this concept, we show in this study that adult Rag1-/- recipient mice of Il23rgfp/+ (IL-23R reporter) bone marrow selectively lack IL-23R+ ??T17 cells. Despite their absence in secondary lymphoid tissues during homeostasis, ??T...     »
Journal title abbreviation:
J Immunol
Year:
2017
Journal volume:
199
Journal issue:
8
Pages contribution:
2668-2679
Language:
eng
Fulltext / DOI:
doi:10.4049/jimmunol.1700287
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28855314
Print-ISSN:
0022-1767
TUM Institution:
Molekulare Immunologie (Prof. Knolle); Neurologische Klinik und Poliklinik
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