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Document type:
Zeitschriftenaufsatz 
Author(s):
Eckert, Stephan; Chang, Yun-Chien; Bayer, Florian P.; The, Matthew; Kuhn, Peer-Hendrik; Weichert, Wilko; Kuster, Bernhard 
Title:
Evaluation of Disposable Trap Column nanoLC–FAIMS–MS/MS for the Proteomic Analysis of FFPE Tissue 
Abstract:
Proteomic biomarker discovery using formalin-fixed paraffin-embedded (FFPE) tissue requires robust workflows to support the analysis of large cohorts of patient samples. It also requires finding a reasonable balance between achieving a high proteomic depth and limiting the overall analysis time. To this end, we evaluated the merits of online coupling of single-use disposable trap column nanoflow liquid chromatography, high-field asymmetric-waveform ion-mobility spectrometry (FAIMS), and tandem m...    »
 
Keywords:
BayBioMS; FFPE analysis; LC−FAIMS−MS/MS; clinical proteomics; high-field asymmetric waveform ion mobility spectrometry (FAIMS); quantitative proteomics 
Journal title:
Journal of Proteome Research 
Year:
2021 
Publisher:
American Chemical Society (ACS) 
E-ISSN:
1535-38931535-3907 
Date of publication:
04.11.2021