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Title:

Functional expression of electrogenic sodium bicarbonate cotransporter 1 (NBCe1) in mouse cortical astrocytes is dependent on S255‐257 and regulated by mTOR

Document type:
Zeitschriftenaufsatz
Author(s):
Khakipoor, Shokoufeh; Giannaki, Marina; Theparambil, Shefeeq M.; Zecha, Jana; Küster, Bernhard; Heermann, Stephan; Deitmer, Joachim W.; Roussa, Eleni
Abstract:
The electrogenic sodium bicarbonate cotransporter 1, NBCe1 (SLC4A4), is the major bicarbonate transporter expressed in astrocytes. It is highly sensitive for bicarbonate and the main regulator of intracellular, extracellular, and synaptic pH, thereby modulating neuronal excitability. However, despite these essential functions, the molecular mechanisms underlying NBCe1-mediated astrocytic response to extracellular pH changes are mostly unknown. Using primary mouse cortical astrocyte cultures, we...     »
Keywords:
BayBioMS; acid-base; alkalosis; bicarbonate; glial cells; pH; signaling
Journal title:
Glia
Year:
2019
Fulltext / DOI:
doi:10.1002/glia.23682
Publisher:
Wiley
E-ISSN:
0894-14911098-1136
Date of publication:
18.07.2019
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