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Title:

Complex Bacterial Consortia Reprogram the Colitogenic Activity of Enterococcus faecalis in a Gnotobiotic Mouse Model of Chronic, Immune-Mediated Colitis

Document type:
Zeitschriftenaufsatz
Author(s):
Lengfelder, Isabella; Sava, Irina G.; Hansen, Jonathan J.; Kleigrewe, Karin; Herzog, Jeremy; Neuhaus, Klaus; Hofmann, Thomas; Sartor, R. Balfour; Haller, Dirk
Abstract:
Inflammatory bowel diseases (IBD) are associated with compositional and functional changes of the intestinal microbiota, but specific contributions of individual bacteria to chronic intestinal inflammation remain unclear. Enterococcus faecalis is a resident member of the human intestinal core microbiota that has been linked to the pathogenesis of IBD and induces chronic colitis in susceptible monoassociated IL-10-deficient (IL-10−/−) mice. In this study, we characterized the colitogenic activity...     »
Keywords:
BayBioMS; Enterococcus faecalis, ethanolamine utilization, gnotobiotic mouse models, microbial consortium, SIHUMI, IBD, IL-10 deficient mouse, RNA sequencing
Journal title:
Frontiers in Immunology
Year:
2019
Journal volume:
10
Fulltext / DOI:
doi:10.3389/fimmu.2019.01420
Publisher:
Frontiers Media SA
E-ISSN:
1664-3224
Date of publication:
20.06.2019
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