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Titel:

Challenges in Clinical Metaproteomics Highlighted by the Analysis of Acute Leukemia Patients with Gut Colonization by Multidrug-Resistant Enterobacteriaceae

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Rechenberger, Julia; Samaras, Patroklos; Jarzab, Anna; Behr, Juergen; Frejno, Martin; Djukovic, Ana; Sanz, Jaime; González-Barberá, Eva; Salavert, Miguel; López-Hontangas, Jose; Xavier, Karina; Debrauwer, Laurent; Rolain, Jean-Marc; Sanz, Miguel; Garcia-Garcera, Marc; Wilhelm, Mathias; Ubeda, Carles; Kuster, Bernhard
Abstract:
The microbiome has a strong impact on human health and disease and is, therefore, increasingly studied in a clinical context. Metaproteomics is also attracting considerable attention, and such data can be efficiently generated today owing to improvements in mass spectrometry-based proteomics. As we will discuss in this study, there are still major challenges notably in data analysis that need to be overcome. Here, we analyzed 212 fecal samples from 56 hospitalized acute leukemia patients with mu...     »
Stichworte:
BayBioMS; human gut microbiome; metaproteome; data analysis; mass spectrometry; proteomics; clinical proteomics; multi-omics; multidrug-resistant Enterobacteriaceae
Zeitschriftentitel:
Proteomes
Jahr:
2019
Band / Volume:
7
Heft / Issue:
1
Seitenangaben Beitrag:
2
Volltext / DOI:
doi:10.3390/proteomes7010002
Verlag / Institution:
MDPI AG
E-ISSN:
2227-7382
Publikationsdatum:
08.01.2019
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