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Title:

Hyperoxaluria Requires TNF Receptors to Initiate Crystal Adhesion and Kidney Stone Disease.

Document type:
Journal Article
Author(s):
Mulay, Shrikant R; Eberhard, Jonathan N; Desai, Jyaysi; Marschner, Julian A; Kumar, Santhosh V R; Weidenbusch, Marc; Grigorescu, Melissa; Lech, Maciej; Eltrich, Nuru; Müller, Lisa; Hans, Wolfgang; Hrab? de Angelis, Martin; Vielhauer, Volker; Hoppe, Bernd; Asplin, John; Burzlaff, Nicolai; Herrmann, Martin; Evan, Andrew; Anders, Hans-Joachim
Abstract:
Intrarenal crystals trigger inflammation and renal cell necroptosis, processes that involve TNF receptor (TNFR) signaling. Here, we tested the hypothesis that TNFRs also have a direct role in tubular crystal deposition and progression of hyperoxaluria-related CKD. Immunohistochemical analysis revealed upregulated tubular expression of TNFR1 and TNFR2 in human and murine kidneys with calcium oxalate (CaOx) nephrocalcinosis-related CKD compared with controls. Western blot and mRNA expression analy...     »
Journal title abbreviation:
J Am Soc Nephrol
Year:
2017
Journal volume:
28
Journal issue:
3
Pages contribution:
761-768
Fulltext / DOI:
doi:10.1681/ASN.2016040486
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27612997
Print-ISSN:
1046-6673
TUM Institution:
Fachgebiet Nephrologie (Prof. Heemann)
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