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Title:

The plasma protein binding of the endogenous glucocorticosteroids is of vital importance for the concentrations in hair and saliva.

Document type:
Zeitschriftenaufsatz
Author(s):
Krumbholz A, Schoenfelder M, Hofmann H, Thieme D
Abstract:
Background: The endogenous glucocorticosteroid cortisol (F) and its metabolite cortisone (E) are known to be involved in stress adaption and anti-inflammatory and immune regulatory effects. The ratios of F to E in the matrices serum, hair and saliva are different. The shift of this ratio by the enzyme activity of 11bhydroxysteroid-dehydrogenase, which inactivates cortisol, was often discussed. The aim of our study was to calculate the contribution of the plasma protein binding (PPB) to this s...     »
Keywords:
Cortisol, Cortisone, Plasma protein binding, Hair, Saliva, LC–MS/MS
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit; 790 Sport, Spiele, Unterhaltung
Journal title:
Forensic Science International
Year:
2018
Year / month:
2018-02
Month:
Feb
Journal issue:
286
Pages contribution:
23-30
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1016/j.forsciint.2018.01.030
Publisher:
Elsevier
Print-ISSN:
0379-0738
Impact Factor:
2.307
Semester:
WS 17-18
TUM Institution:
Sportbiologie
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