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Titel:

The muscle size-regulating enzyme PKM2 limits myofiber growth in vitro and increases in response to resistance exercise in human skeletal muscle

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Verbrugge S, Gehlert S, Stadhouders L, Jacko D, Aussieker T, de Wit G, Offringa C, Schönfelder M, Jaspers R, Wackerhage H
Abstract:
Nearly 100 years ago, Otto Warburg investigated the metabolism of growing tissues and discovered that tumors reprogram their metabolism. It is poorly understood whether and how hypertrophying muscle, another growing tissue, reprograms its metabolism too. Here, we studied pyruvate kinase muscle (PKM), which can be spliced into two isoforms (PKM1, PKM2). This is of interest, because PKM2 redirects glycolytic flux towards biosynthetic pathways, which might contribute to muscle hypertrophy too. We f...     »
Stichworte:
Warburg effect; pyruvate kinase; insulin-like growth factor 1; glycolysis; skeletal muscle; hypertrophy; resistance exercise; metabolic reprogramming; cancer
Dewey Dezimalklassifikation:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit
Zeitschriftentitel:
International Journal of Molecular Sciences -Biochemistry
Jahr:
2020
Jahr / Monat:
2020-09
Quartal:
3. Quartal
Monat:
Sep
Reviewed:
ja
Sprache:
en
Volltext / DOI:
doi:10.3390/ijms21197062
WWW:
https://www.mdpi.com/journal/ijms/sections/biochemistry
Print-ISSN:
1422-0067
Impact Factor:
4,556
Scimago-Quartil:
Q1
Hinweise:
SCImago Journal &  Country Rank
Angenommen (von Zeitschrift):
23.09.2020
Semester:
SS 20
TUM Einrichtung:
Sportbiologie
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