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Title:

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.

Document type:
Journal Article; Research Support, Non-U.S. Gov't
Author(s):
Jung, Bomi; Messias, Ana C; Schorpp, Kenji; Geerlof, Arie; Schneider, Günter; Saur, Dieter; Hadian, Kamyar; Sattler, Michael; Wanker, Erich E; Hasenöder, Stefan; Lickert, Heiko
Abstract:
Trafficking of the G protein-coupled receptor (GPCR) Smoothened (Smo) to the primary cilium (PC) is a potential target to inhibit oncogenic Hh pathway activation in a large number of tumors. One drawback is the appearance of Smo mutations that resist drug treatment, which is a common reason for cancer treatment failure. Here, we undertook a high content screen with compounds in preclinical or clinical development and identified ten small molecules that prevent constitutive active mutant SmoM2 tr...     »
Journal title abbreviation:
Sci Rep
Year:
2016
Journal volume:
6
Pages contribution:
22540
Language:
eng
Fulltext / DOI:
doi:10.1038/srep22540
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/26931153
Print-ISSN:
2045-2322
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie)
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