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Title:

Transcriptome-based profiling of yolk sac-derived macrophages reveals a role for Irf8 in macrophage maturation.

Document type:
Journal Article; 16
Author(s):
Hagemeyer, Nora; Kierdorf, Katrin; Frenzel, Kathrin; Xue, Jia; Ringelhan, Marc; Abdullah, Zeinab; Godin, Isabelle; Wieghofer, Peter; Costa Jordão, Marta Joana; Ulas, Thomas; Yorgancioglu, Gülden; Rosenbauer, Frank; Knolle, Percy A; Heikenwälder, Mathias; Schultze, Joachim L; Prinz, Marco
Abstract:
Recent studies have shown that tissue macrophages (M?) arise from embryonic progenitors of the yolk sac (YS) and fetal liver and colonize tissues before birth. Further studies have proposed that developmentally distinct tissue M? can be identified based on the differential expression of F4/80 and CD11b, but whether a characteristic transcriptional profile exists is largely unknown. Here, we took advantage of an inducible fate-mapping system that facilitated the identification of CD45(+)c-kit(-)C...     »
Journal title abbreviation:
EMBO J
Year:
2016
Journal volume:
35
Journal issue:
16
Pages contribution:
1730-44
Language:
eng
Fulltext / DOI:
doi:10.15252/embj.201693801
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27412700
Print-ISSN:
0261-4189
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Roman Herzog Comprehensive Cancer Center
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