No Detrimental Effect of a Positive Family History on Long-Term Outcomes Following Radical Prostatectomy.

Brath, Johannes M S; Grill, Sonja; Ankerst, Donna P; Thompson, Ian M; Gschwend, Juergen E; Herkommer, Kathleen

doi:10.1016/j.juro.2015.07.097

journal article

Titel:: No Detrimental Effect of a Positive Family History on Long-Term Outcomes Following Radical Prostatectomy.
Dokumenttyp:: Journal Article; Article
Autor(en):: Brath, Johannes M S; Grill, Sonja; Ankerst, Donna P; Thompson, Ian M; Gschwend, Juergen E; Herkommer, Kathleen
Abstract:: Overall 1 in 5 patients with prostate cancer has a positive family history. In this report we evaluated the association between family history and long-term outcomes following radical prostatectomy.Patients treated with radical prostatectomy were identified from a German registry, and separated into positive first-degree family history vs negative family history (strictly negative, requiring at least 1 male first-degree relative older than 60 years and no prostate cancer in the family). Kaplan-Meier curves and Cox proportional hazards models were used for association analyses with biochemical recurrence-free and prostate cancer specific survival.Median followup for 7,690 men included in the study was 8.4 years. Of the 754 younger patients less than 55 years old 50.9% (384) had a family history compared to 40.4% of the older patients (2,803; p <0.001). The 10-year biochemical recurrence-free (62.5%) and prostate cancer specific survival (96.1%) rates did not differ between patients with vs without a family history, nor between the younger vs older patient groups (all p >0.05). Prostate specific antigen, pathological stage, node stage and Gleason score were the only significant predictors for biochemical recurrence-free survival, while pathological stage, node stage (all p <0.005) and Gleason score (Gleason 7 vs 6 or less-HR 1.711, 95% CI 1.056-2.774, p = 0.03; Gleason 8 or greater vs 6 or less-HR 4.516, 95% CI 2.776-7.347, p <0.0001) were the only predictors for prostate cancer specific survival.A family history of prostate cancer has no bearing on long-term outcomes after radical prostatectomy.
Zeitschriftentitel:: J Urol
Jahr:: 2016
Band / Volume:: 195
Heft / Issue:: 2
Seitenangaben Beitrag:: 343-8
Sprache:: eng
Volltext / DOI:: doi:10.1016/j.juro.2015.07.097
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/26239337
Print-ISSN:: 0022-5347
TUM Einrichtung:: Urologische Klinik und Poliklinik
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Urologie (Prof. Gschwend)2016