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Title:

RIG-I/MAVS and STING signaling promote gut integrity during irradiation- and immune-mediated tissue injury.

Document type:
Journal Article; Article
Author(s):
Fischer, Julius C; Bscheider, Michael; Eisenkolb, Gabriel; Lin, Chia-Ching; Wintges, Alexander; Otten, Vera; Lindemans, Caroline A; Heidegger, Simon; Rudelius, Martina; Monette, Sébastien; Porosnicu Rodriguez, Kori A; Calafiore, Marco; Liebermann, Sophie; Liu, Chen; Lienenklaus, Stefan; Weiss, Siegfried; Kalinke, Ulrich; Ruland, Jürgen; Peschel, Christian; Shono, Yusuke; Docampo, Melissa; Velardi, Enrico; Jenq, Robert R; Hanash, Alan M; Dudakov, Jarrod A; Haas, Tobias; van den Brink, Marcel R M;...     »
Abstract:
The molecular pathways that regulate the tissue repair function of type I interferon (IFN-I) during acute tissue damage are poorly understood. We describe a protective role for IFN-I and the RIG-I/MAVS signaling pathway during acute tissue damage in mice. Mice lacking mitochondrial antiviral-signaling protein (MAVS) were more sensitive to total body irradiation- and chemotherapy-induced intestinal barrier damage. These mice developed worse graft-versus-host disease (GVHD) in a preclinical model...     »
Journal title abbreviation:
Sci Transl Med
Year:
2017
Journal volume:
9
Journal issue:
386
Language:
eng
Fulltext / DOI:
doi:10.1126/scitranslmed.aag2513
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28424327
Print-ISSN:
1946-6234
TUM Institution:
III. Medizinische Klinik und Poliklinik (Hämatologie / Onkologie); Institut für Klinische Chemie und Pathobiochemie
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