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Title:

Express incorporation of membrane proteins from various human cell types into phospholipid bilayer nanodiscs.

Document type:
Comparative Study; Journal Article; Comparative Study; Journal Article
Author(s):
Mak, Stefanie; Sun, Ruoyu; Schmalenberg, Michael; Peters, Carsten; Luppa, Peter B
Abstract:
Analysis of membrane proteins is still inadequately represented in diagnostics despite their importance as drug targets and biomarkers. One main reason is the difficult handling caused by their insolubility in aqueous buffer solutions. The nanodisc technology was developed to circumvent this challenge and enables analysis of membrane proteins with standard research methods. However, existing nanodisc generation protocols rely on time-consuming membrane isolation and protein purification from ove...     »
Journal title abbreviation:
Biochem J
Year:
2017
Journal volume:
474
Journal issue:
8
Pages contribution:
1361-1371
Language:
eng
Fulltext / DOI:
doi:10.1042/BCJ20161110
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28246334
Print-ISSN:
0264-6021
TUM Institution:
Institut für Klinische Chemie und Pathobiochemie
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