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Titel:

Antibody blockade of CLEC12A delays EAE onset and attenuates disease severity by impairing myeloid cell CNS infiltration and restoring positive immunity.

Dokumenttyp:
Journal Article; Journal Article
Autor(en):
Sagar, Divya; Singh, Narendra P; Ginwala, Rashida; Huang, Xiaofang; Philip, Ramila; Nagarkatti, Mitzi; Nagarkatti, Prakash; Neumann, Konstantin; Ruland, Jürgen; Andrews, Allison M; Ramirez, Servio H; Khan, Zafar K; Jain, Pooja
Abstract:
The mechanism of dendritic cells (DCs) recruitment across the blood brain barrier (BBB) during neuroinflammation has been the least explored amongst all leukocytes. For cells of myeloid origin, while integrins function at the level of adhesion, the importance of lectins remains unknown. Here, we identified functions of one C-type lectin receptor, CLEC12A, in facilitating DC binding and transmigration across the BBB in response to CCL2 chemotaxis. To test function of CLEC12A in an animal model of...     »
Zeitschriftentitel:
Sci Rep
Jahr:
2017
Band / Volume:
7
Heft / Issue:
1
Seitenangaben Beitrag:
2707
Sprache:
eng
Volltext / DOI:
doi:10.1038/s41598-017-03027-x
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28578388
Print-ISSN:
2045-2322
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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