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Titel:

Card9-dependent IL-1? regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Journal Article
Autor(en):
Bergmann, Hanna; Roth, Susanne; Pechloff, Konstanze; Kiss, Elina A; Kuhn, Sabine; Heikenwälder, Mathias; Diefenbach, Andreas; Greten, Florian R; Ruland, Jürgen
Abstract:
Inflammatory bowel diseases (IBD) are key risk factors for the development of colorectal cancer, but the mechanisms that link intestinal inflammation with carcinogenesis are insufficiently understood. Card9 is a myeloid cell-specific signaling protein that regulates inflammatory responses downstream of various pattern recognition receptors and which cooperates with the inflammasomes for IL-1? production. Because polymorphisms in Card9 were recurrently associated with human IBD, we investigated t...     »
Zeitschriftentitel:
Eur J Immunol
Jahr:
2017
Band / Volume:
47
Heft / Issue:
8
Seitenangaben Beitrag:
1342-1353
Sprache:
eng
Volltext / DOI:
doi:10.1002/eji.201646765
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28586167
Print-ISSN:
0014-2980
TUM Einrichtung:
Institut für Klinische Chemie und Pathobiochemie
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