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Title:

The Hippo signal transduction network in skeletal and cardiac muscle

Document type:
Zeitschriftenaufsatz
Author(s):
Wackerhage H, Del Re DP, Judson RN, Sudol M, Sadoshima J
Abstract:
The discovery of the Hippo pathway can be traced back to two areas of research. Genetic screens in fruit flies led to the identification of the Hippo pathway kinases and scaffolding proteins that function together to suppress cell proliferation and tumor growth. Independent research, often in the context of muscle biology, described Tead (TEA domain) transcription factors, which bind CATTCC DNA motifs to regulate gene expression. These two research areas were joined by the finding that the Hippo...     »
Dewey Decimal Classification:
570 Biowissenschaften, Biologie; 610 Medizin und Gesundheit
Journal title:
Science Signaling
Year:
2014
Journal volume:
7
Journal issue:
337
Language:
en
Fulltext / DOI:
doi:10.1126/scisignal.2005096
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25097035
Publisher:
Science
E-ISSN:
1937-9145
Impact Factor:
6.4
TUM Institution:
Sportbiologie
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