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Titel:

Age dictates a steroid-resistant cascade of Wnt5a, transglutaminase 2, and leukotrienes in inflamed airways.

Dokumenttyp:
Journal Article
Autor(en):
Dietz, Katharina; de Los Reyes Jiménez, Marta; Gollwitzer, Eva S; Chaker, Adam M; Zissler, Ulrich M; Rådmark, Olof P; Baarsma, Hoeke A; Königshoff, Melanie; Schmidt-Weber, Carsten B; Marsland, Benjamin J; Esser-von Bieren, Julia
Abstract:
Airway remodeling is a detrimental and refractory process showing age-dependent clinical manifestations that are mechanistically undefined. The leukotriene (LT) and wingless/integrase (Wnt) pathways have been implicated in remodeling, but age-specific expression profiles and common regulators remained elusive.We sought to study the activation of the LT and Wnt pathways during early- or late-onset allergic airway inflammation and to address regulatory mechanisms and clinical relevance in normal h...     »
Zeitschriftentitel:
J Allergy Clin Immunol
Jahr:
2017
Band / Volume:
139
Heft / Issue:
4
Seitenangaben Beitrag:
1343-1354.e6
Sprache:
eng
Volltext / DOI:
doi:10.1016/j.jaci.2016.07.014
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27554815
Print-ISSN:
0091-6749
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik; Molekulare Allergologie (Prof. Schmidt-Weber)
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