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Titel:

Does cefuroxime alter fracture healing in vivo? A micro-computertomographic, biomechanical, and histomorphometric evaluation using a rat fracture model.

Dokumenttyp:
Journal Article
Autor(en):
Bissinger, Oliver; Kreutzer, Kilian; Wolff, Klaus-Dietrich; Wexel, Gabriele; Hapfelmeier, Alexander; Pautke, Christoph; Vogt, Stephan; Michael Prodinger, Peter; Tischer, Thomas
Abstract:
Cefuroxime is widely used for antibiotic prophylaxis in orthopedic surgery. However, a recent study indicated a dose-dependent reduction in osteoblast function in vitro. Nevertheless, cell culture might not sufficiently imitate the complex process of bone remodeling. As data concerning possible in vivo interactions of cefuroxime on fracture healing are completely missing, we investigated the following hypothesis: Does Cefuroxime impair bone healing in vivo? Therefore, 34 male Wistar rats were ra...     »
Zeitschriftentitel:
J Biomed Mater Res B Appl Biomater
Jahr:
2017
Band / Volume:
105
Heft / Issue:
8
Seitenangaben Beitrag:
2282-2291
Sprache:
eng
Volltext / DOI:
doi:10.1002/jbm.b.33759
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/27460791
Print-ISSN:
1552-4973
TUM Einrichtung:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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