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Title:

Does cefuroxime alter fracture healing in vivo? A micro-computertomographic, biomechanical, and histomorphometric evaluation using a rat fracture model.

Document type:
Journal Article
Author(s):
Bissinger, Oliver; Kreutzer, Kilian; Wolff, Klaus-Dietrich; Wexel, Gabriele; Hapfelmeier, Alexander; Pautke, Christoph; Vogt, Stephan; Michael Prodinger, Peter; Tischer, Thomas
Abstract:
Cefuroxime is widely used for antibiotic prophylaxis in orthopedic surgery. However, a recent study indicated a dose-dependent reduction in osteoblast function in vitro. Nevertheless, cell culture might not sufficiently imitate the complex process of bone remodeling. As data concerning possible in vivo interactions of cefuroxime on fracture healing are completely missing, we investigated the following hypothesis: Does Cefuroxime impair bone healing in vivo? Therefore, 34 male Wistar rats were ra...     »
Journal title abbreviation:
J Biomed Mater Res B Appl Biomater
Year:
2017
Journal volume:
105
Journal issue:
8
Pages contribution:
2282-2291
Language:
eng
Fulltext / DOI:
doi:10.1002/jbm.b.33759
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27460791
Print-ISSN:
1552-4973
TUM Institution:
Institut für Medizinische Statistik und Epidemiologie; Klinik und Poliklinik für Mund-, Kiefer- und Gesichtschirurgie
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