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Title:

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice.

Document type:
Journal Article; Research Support, Non-U.S. Gov't; Article
Author(s):
Clemmensen, Christoffer; Finan, Brian; Fischer, Katrin; Tom, Robby Zachariah; Legutko, Beata; Sehrer, Laura; Heine, Daniela; Grassl, Niklas; Meyer, Carola W; Henderson, Bart; Hofmann, Susanna M; Tschöp, Matthias H; Van der Ploeg, Lex H T; Müller, Timo D
Abstract:
We assessed the efficacy of simultaneous agonism at the glucagon-like peptide-1 receptor (GLP-1R) and the melanocortin-4 receptor (MC4R) for the treatment of obesity and diabetes in rodents. Diet-induced obese (DIO) mice were chronically treated with either the long-acting GLP-1R agonist liraglutide, the MC4R agonist RM-493 or a combination of RM-493 and liraglutide. Co-treatment of DIO mice with RM-493 and liraglutide improves body weight loss and enhances glycemic control and cholesterol metab...     »
Journal title abbreviation:
EMBO Mol Med
Year:
2015
Journal volume:
7
Journal issue:
3
Pages contribution:
288-98
Language:
eng
Fulltext / DOI:
doi:10.15252/emmm.201404508
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25652173
Print-ISSN:
1757-4676
TUM Institution:
Kliniken und Institute
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