Benutzer: Gast  Login
Titel:

Dual melanocortin-4 receptor and GLP-1 receptor agonism amplifies metabolic benefits in diet-induced obese mice.

Dokumenttyp:
Journal Article; Research Support, Non-U.S. Gov't; Article
Autor(en):
Clemmensen, Christoffer; Finan, Brian; Fischer, Katrin; Tom, Robby Zachariah; Legutko, Beata; Sehrer, Laura; Heine, Daniela; Grassl, Niklas; Meyer, Carola W; Henderson, Bart; Hofmann, Susanna M; Tschöp, Matthias H; Van der Ploeg, Lex H T; Müller, Timo D
Abstract:
We assessed the efficacy of simultaneous agonism at the glucagon-like peptide-1 receptor (GLP-1R) and the melanocortin-4 receptor (MC4R) for the treatment of obesity and diabetes in rodents. Diet-induced obese (DIO) mice were chronically treated with either the long-acting GLP-1R agonist liraglutide, the MC4R agonist RM-493 or a combination of RM-493 and liraglutide. Co-treatment of DIO mice with RM-493 and liraglutide improves body weight loss and enhances glycemic control and cholesterol metab...     »
Zeitschriftentitel:
EMBO Mol Med
Jahr:
2015
Band / Volume:
7
Heft / Issue:
3
Seitenangaben Beitrag:
288-98
Sprache:
eng
Volltext / DOI:
doi:10.15252/emmm.201404508
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/25652173
Print-ISSN:
1757-4676
TUM Einrichtung:
Kliniken und Institute
 BibTeX