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Title:

Metabolic Activation of Intrahepatic CD8(+) T Cells and NKT Cells Causes Nonalcoholic Steatohepatitis and Liver Cancer via Cross-Talk with Hepatocytes.

Document type:
Journal Article; Article
Author(s):
Wolf, Monika Julia; Adili, Arlind; Piotrowitz, Kira; Abdullah, Zeinab; Boege, Yannick; Stemmer, Kerstin; Ringelhan, Marc; Simonavicius, Nicole; Egger, Michèle; Wohlleber, Dirk; Lorentzen, Anna; Einer, Claudia; Schulz, Sabine; Clavel, Thomas; Protzer, Ulrike; Thiele, Christoph; Zischka, Hans; Moch, Holger; Tschöp, Matthias; Tumanov, Alexei V; Haller, Dirk; Unger, Kristian; Karin, Michael; Kopf, Manfred; Knolle, Percy; Weber, Achim; Heikenwälder, Mathias
Abstract:
Hepatocellular carcinoma (HCC), the fastest rising cancer in the United States and increasing in Europe, often occurs with nonalcoholic steatohepatitis (NASH). Mechanisms underlying NASH and NASH-induced HCC are largely unknown. We developed a mouse model recapitulating key features of human metabolic syndrome, NASH, and HCC by long-term feeding of a choline-deficient high-fat diet. This induced activated intrahepatic CD8(+) T cells, NKT cells, and inflammatory cytokines, similar to NASH patient...     »
Journal title abbreviation:
Cancer Cell
Year:
2014
Journal volume:
26
Journal issue:
4
Pages contribution:
549-64
Language:
eng
Fulltext / DOI:
doi:10.1016/j.ccell.2014.09.003
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/25314080
Print-ISSN:
1535-6108
TUM Institution:
II. Medizinische Klinik und Poliklinik (Gastroenterologie); Institut für Virologie ; Kliniken und Institute; Roman Herzog Comprehensive Cancer Center
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