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Titel:

Improved efficacy of allergen-specific immunotherapy by JAK inhibition in a murine model of allergic asthma.

Dokumenttyp:
Journal Article
Autor(en):
Aguilar-Pimentel, Antonio; Graessel, Anke; Alessandrini, Francesca; Fuchs, Helmut; Gailus-Durner, Valerie; Hrab? de Angelis, Martin; Russkamp, Dennis; Chaker, Adam; Ollert, Markus; Blank, Simon; Gutermuth, Jan; Schmidt-Weber, Carsten B
Abstract:
Allergen-specific immunotherapy (AIT) is the only curative treatment for type-1 allergies, but sometimes shows limited therapeutic response as well as local and systemic side effects. Limited control of local inflammation and patient symptoms hampers its widespread use in severe allergic asthma.Our aim was to evaluate whether AIT is more effective in suppression of local inflammation if performed under the umbrella of short-term non-specific immunomodulation using a small molecule inhibitor of J...     »
Zeitschriftentitel:
PLoS ONE
Jahr:
2017
Band / Volume:
12
Heft / Issue:
6
Seitenangaben Beitrag:
e0178563
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pone.0178563
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28570653
Print-ISSN:
1932-6203
TUM Einrichtung:
Hals-Nasen-Ohrenklinik und Poliklinik; Molekulare Allergologie (Prof. Schmidt-Weber)
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