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Title:

Targeting PI3K/mTOR signaling exerts potent antitumor activity in pheochromocytoma in vivo.

Document type:
Journal Article
Author(s):
Lee, Misu; Minaskan, Ninelia; Wiedemann, Tobias; Irmler, Martin; Beckers, Johannes; Yousefi, Behrooz H; Kaissis, Georgios; Braren, Rickmer; Laitinen, Iina; Pellegata, Natalia S
Abstract:
Pheochromocytomas (PCCs) are mostly benign tumors, amenable to complete surgical resection. However, 10-17% of cases can become malignant, and once metastasized, there is no curative treatment for this disease. Given the need to identify the effective therapeutic approaches for PCC, we evaluated the antitumor potential of the dual-PI3K/mTOR inhibitor BEZ235 against these tumors. We employed an in vivo model of endogenous PCCs (MENX mutant rats), which closely recapitulate the human tumors. Mutan...     »
Journal title abbreviation:
Endocr Relat Cancer
Year:
2017
Journal volume:
24
Journal issue:
1
Pages contribution:
1-15
Language:
eng
Fulltext / DOI:
doi:10.1530/ERC-16-0324
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/27811202
Print-ISSN:
1351-0088
TUM Institution:
Klinik und Poliklinik für Nuklearmedizin
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