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Title:

Tweety-Homolog 1 Drives Brain Colonization of Gliomas.

Document type:
Journal Article
Author(s):
Jung, Erik; Osswald, Matthias; Blaes, Jonas; Wiestler, Benedikt; Sahm, Felix; Schmenger, Torsten; Solecki, Gergely; Deumelandt, Katrin; Kurz, Felix T; Xie, Ruifan; Weil, Sophie; Heil, Oliver; Thomé, Carina; Gömmel, Miriam; Syed, Mustafa; Häring, Peter; Huber, Peter E; Heiland, Sabine; Platten, Michael; von Deimling, Andreas; Wick, Wolfgang; Winkler, Frank
Abstract:
Early and progressive colonization of the healthy brain is one hallmark of diffuse gliomas, including glioblastomas. We recently discovered ultralong (>10 to hundreds of microns) membrane protrusions [tumor microtubes (TMs)] extended by glioma cells. TMs have been associated with the capacity of glioma cells to effectively invade the brain and proliferate. Moreover, TMs are also used by some tumor cells to interconnect to one large, resistant multicellular network. Here, we performed a correlati...     »
Journal title abbreviation:
J Neurosci
Year:
2017
Journal volume:
37
Journal issue:
29
Pages contribution:
6837-6850
Language:
eng
Fulltext / DOI:
doi:10.1523/JNEUROSCI.3532-16.2017
Pubmed ID:
http://view.ncbi.nlm.nih.gov/pubmed/28607172
Print-ISSN:
0270-6474
TUM Institution:
Fachgebiet Neuroradiologie (Prof. Zimmer)
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