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Titel:

TCF21 and the environmental sensor aryl-hydrocarbon receptor cooperate to activate a pro-inflammatory gene expression program in coronary artery smooth muscle cells.

Dokumenttyp:
Journal Article; Article
Autor(en):
Kim, Juyong Brian; Pjanic, Milos; Nguyen, Trieu; Miller, Clint L; Iyer, Dharini; Liu, Boxiang; Wang, Ting; Sazonova, Olga; Carcamo-Orive, Ivan; Matic, Ljubica Perisic; Maegdefessel, Lars; Hedin, Ulf; Quertermous, Thomas
Abstract:
Both environmental factors and genetic loci have been associated with coronary artery disease (CAD), however gene-gene and gene-environment interactions that might identify molecular mechanisms of risk are not easily studied by human genetic approaches. We have previously identified the transcription factor TCF21 as the causal CAD gene at 6q23.2 and characterized its downstream transcriptional network that is enriched for CAD GWAS genes. Here we investigate the hypothesis that TCF21 interacts wi...     »
Zeitschriftentitel:
PLoS Genet
Jahr:
2017
Band / Volume:
13
Heft / Issue:
5
Seitenangaben Beitrag:
e1006750
Sprache:
eng
Volltext / DOI:
doi:10.1371/journal.pgen.1006750
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/28481916
Print-ISSN:
1553-7390
TUM Einrichtung:
Fachgebiet Gefäßchirurgie (Prof. Eckstein)
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