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Title:

Depsipeptide Intermediates Interrogate Proposed Biosynthesis of Cereulide, the Emetic Toxin of Bacillus cereus

Document type:
Zeitschriftenaufsatz
Author(s):
Marxen, Sandra; Stark, Timo D.; Rütschle, Andrea; Lücking, Genia; Frenzel, Elrike; Scherer, Siegfried; Ehling-Schulz, Monika; Hofmann, Thomas
Abstract:
Cereulide and isocereulides A-G are biosynthesized as emetic toxins by Bacillus cereus via a non-ribosomal peptide synthetase (NRPS) called Ces. Although a thiotemplate mechanisms involving cyclo-trimerization of ready-made D-O-Leu-D-Ala-L-O-Val-L-Val via a thioesterase (TE) domain is proposed for cereulide biosynthesis, the exact mechanism is far from being understood. UPLC-TOF MS analysis of B. cereus strains in combination with (13)C-labeling experiments now revealed tetra-, octa-, and dodeca...     »
Keywords:
BayBioMS
Journal title:
Scientific Reports
Year:
2015
Journal volume:
5
Pages contribution:
10637
Fulltext / DOI:
doi:10.1038/srep10637
Publisher:
Springer Nature
E-ISSN:
2045-2322
Date of publication:
27.05.2015
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