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Titel:

Dynamically evolving novel overlapping gene as a factor in the SARS-CoV-2 pandemic

Dokumenttyp:
Zeitschriftenaufsatz
Autor(en):
Nelson, Chase W; Ardern, Zachary; Goldberg, Tony L; Meng, Chen; Kuo, Chen-Hao; Ludwig, Christina; Kolokotronis, Sergios-Orestis; Wei, Xinzhu
Abstract:
Understanding the emergence of novel viruses requires an accurate and comprehensive annotation of their genomes. Overlapping genes (OLGs) are common in viruses and have been associated with pandemics, but are still widely overlooked. We identify and characterize ORF3d, a novel OLG in SARS-CoV-2 that is also present in Guangxi pangolin-CoVs but not other closely related pangolin-CoVs or bat-CoVs. We then document evidence of ORF3d translation, characterize its protein sequence, and conduct an evo...     »
Stichworte:
BayBioMS; evolutionary biology; infectious disease; microbiology; viruses
Zeitschriftentitel:
eLife
Jahr:
2020
Band / Volume:
9
Volltext / DOI:
doi:10.7554/elife.59633
Verlag / Institution:
eLife Sciences Publications, Ltd
E-ISSN:
2050-084X
Publikationsdatum:
01.10.2020
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