Resection of Motor Eloquent Metastases Aided by Preoperative nTMS-Based Motor Maps-Comparison of Two Observational Cohorts.

Krieg, Sandro M; Picht, Thomas; Sollmann, Nico; Bährend, Ina; Ringel, Florian; Nagarajan, Srikantan S; Meyer, Bernhard; Tarapore, Phiroz E

doi:10.3389/fonc.2016.00261

journal article

Dokumenttyp:: Journal Article
Autor(en):: Krieg, Sandro M; Picht, Thomas; Sollmann, Nico; Bährend, Ina; Ringel, Florian; Nagarajan, Srikantan S; Meyer, Bernhard; Tarapore, Phiroz E
Titel:: Resection of Motor Eloquent Metastases Aided by Preoperative nTMS-Based Motor Maps-Comparison of Two Observational Cohorts.
Abstract:: Preoperative mapping of motor areas with navigated transcranial magnetic stimulation (nTMS) has been shown to improve surgical outcomes for peri-Rolandic lesions and, in particular, for gliomas. However, the impact of this technique on surgical outcomes for peri-Rolandic metastatic lesions is yet unknown.To investigate the impact of nTMS on surgical outcomes for peri-Rolandic metastatic lesions, various clinical parameters were analyzed in our international study group.Two prospectively enrolled cohorts were compared by investigating patients receiving preoperative nTMS (2010-2015; 120 patients) and patients who did not receive preoperative nTMS (2006-2015; 130 patients). Tumor location, pathology, size, and preoperative deficits were comparable.The nTMS group showed a lower rate of residual tumor on postoperative magnetic resonance imaging (odds ratio 0.3025; 95% confidence interval 0.1356-0.6749). On long-term follow-up, surgery-related paresis was decreased in the nTMS group (nTMS vs. non-nTMS; improved: 30.8 vs. 13.1%, unchanged: 65.8 vs. 73.8%, worse: 3.4 vs. 13.1% of patients; p = 0.0002). Moreover, the nTMS group received smaller craniotomies (nTMS: 16.7 ± 8.6 cm(2) vs. non-nTMS: 25.0 ± 17.1 cm(2); p < 0.0001). Surgical time differed significantly between the two groups (nTMS: 128.8 ± 49.4 min vs. non-nTMS: 158.0 ± 65.8 min; p = 0.0002).This non-randomized study suggests that preoperative motor mapping by nTMS may improve the treatment of patients undergoing surgical resection of metastases in peri-Rolandic regions. These findings suggest that further evaluation with a prospective, randomized trial may be warranted.
Zeitschriftentitel:: Front Oncol
Jahr:: 2016
Band / Volume:: 6
Seitenangaben Beitrag:: 261
Sprache:: eng
Volltext / DOI:: doi:10.3389/fonc.2016.00261
PubMed:: http://view.ncbi.nlm.nih.gov/pubmed/28066717
Print-ISSN:: 2234-943X
TUM Einrichtung:: Neurochirurgische Klinik und Poliklinik
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mediaTUM Gesamtbestand Einrichtungen Schools TUM School of Medicine and Health Departments Clinical Medicine Klinik und Poliklinik für Neurochirurgie (Prof. Meyer)2016