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Title:

A comprehensive computational human lung model incorporating inter-acinar dependencies: Application to spontaneous breathing and mechanical ventilation

Document type:
Zeitschriftenaufsatz
Author(s):
Roth C.J., Ismail M., Yoshihara L., Wall W.A.
Abstract:
In this article, we propose a comprehensive computational model of the entire respiratory system which allows simulating patient-specific lungs under different ventilation scenarios and provides a deeper insight into local straining and stressing of pulmonary acini. We include novel 0D inter-acinar linker elements to respect the interplay between neighboring alveoli, an essential feature especially in heterogeneously distended lungs. The model is applicable to healthy and diseased patient-sp...     »
Keywords:
Respiratory mechanics; reduced-dimensional modeling; lung interdependence; acinar model; alveolar overstraining
Dewey Decimal Classification:
620 Ingenieurwissenschaften
Journal title:
International Journal for Numerical Methods in Biomedical Engineering
Year:
2017
Journal volume:
30
Journal issue:
1
Covered by:
Scopus
Reviewed:
ja
Language:
en
Fulltext / DOI:
doi:10.1002/cnm.2787
Status:
Verlagsversion / published
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