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Titel:

ATP protects, by way of receptor-mediated mechanisms, against hypoxia-induced injury in renal proximal tubules.

Dokumenttyp:
Journal Article; Article
Autor(en):
Kribben, A; Feldkamp, T; Horbelt, M; Lange, B; Pietruck, F; Herget-Rosenthal, S; Heemann, U; Philipp, T
Abstract:
We examined the effect of ATP on hypoxia-induced injury in freshly isolated rat renal proximal tubules and compared it with the effects of stable ATP analogues and ATP degradation products. Extracellular ATP significantly reduced hypoxia-induced structural cell damage (lactate dehydrogenase release). P(2)-receptor agonistic ATP analogues, including 2'-methylthio-ATP (2-Me-S-ATP), were also protective. In contrast, the P(1)-agonistic degradation products AMP and adenosine were not protective. Hyp...     »
Zeitschriftentitel:
J Lab Clin Med
Jahr:
2003
Band / Volume:
141
Heft / Issue:
1
Seitenangaben Beitrag:
67-73
Sprache:
eng
Volltext / DOI:
doi:10.1067/mlc.2003.7
PubMed:
http://view.ncbi.nlm.nih.gov/pubmed/12518170
Print-ISSN:
0022-2143
TUM Einrichtung:
Fachgebiet Nephrologie (Prof. Heemann)
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